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Document 2769
DOCN M94A2769
TI Saliva HIV testing among high-risk groups. CSSS Group.
DT 9412
AU Vall M; Casabona J; Rabella N; De Miniac D; Dept. Health, Hosp. S. Pau.
Barcelona, Catalonia, Spain.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):229 (abstract no. PB0347). Unique
Identifier : AIDSLINE ICA10/94369806
AB OBJECTIVE: To compare saliva and serum samples for HIV testing. METHODS:
Duplicate samples of saliva and serum were collected from 286 subjects
at high-risk of HIV infection in three different settings in Barcelona.
HIV testing was done through commercial ELISAs in both samples following
WHO strategy II. Discrepant results between serum and saliva were
further tested with Western blot. RESULTS: The provision of a saliva
sample using a commercial saliva collector was accepted by the
participants without any particular problem, and agreement between
antibody HIV testing using saliva and serum specimens was 98.9% (95%
confidence intervals: 97.7-100). DISCUSSION: If blood samples are not
available saliva is an effective alternative to serum for HIV surveys
among high risk individuals. Furthermore, a three-step protocol similar
to the one we used is an acceptable strategy for epidemiological studies
were data has to be analyzed at the individual level, especially if the
Western blot or other confirmatory tests are further optimized for use
with saliva.
DE Blotting, Western Comparative Study Enzyme-Linked Immunosorbent Assay
Evaluation Studies Human HIV Antibodies/*ANALYSIS/BLOOD HIV
Infections/*DIAGNOSIS/EPIDEMIOLOGY HIV-1/*IMMUNOLOGY Reagent Kits,
Diagnostic Risk Factors Saliva/*IMMUNOLOGY Salivary
Proteins/*ANALYSIS Sensitivity and Specificity Spain/EPIDEMIOLOGY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).